Boosting NAD+ by 142%: What Science Reveals

Posted By Green Ver on August 2025

A human clinical trial shows an impressive increase in NAD+ levels with nicotinamide riboside (NR).

As we age, our natural NAD+ levels decline, affecting energy and vitality. A clinical study published in Nature Communications found that supplementation with nicotinamide riboside (NR) in healthy adults increased NAD+ blood levels by up to 142% in just 8 days with doses of 1–2 g/day (Trammell et al., 2016, Nature Communications).

This groundbreaking research confirms that NAD+ is not just a wellness trend, but a scientifically backed solution to fuel cellular energy, enhance physical performance, and support a vibrant life.

The Study

In a landmark clinical trial published in Nature Communications, researchers evaluated the effects of supplementing with nicotinamide riboside (NR), a well-known precursor of NAD+. Healthy adult participants received daily doses ranging from 1 to 2 grams of NR. Within just 8 days, their blood NAD+ levels increased by up to 142% compared to baseline (Trammell et al., 2016, Nature Communications).

The significance of this study lies not only in the sheer percentage increase but also in the short time frame. Achieving such a dramatic boost in less than two weeks demonstrates how responsive the body can be when provided with the right nutritional support.

What This Means for You

If your energy levels aren’t what they used to be, this research offers hope. A 142% increase in NAD+ translates into better mitochondrial function, which can mean:

Sustained energy throughout the day
Faster post-exercise recovery
Sharper mental clarity
Healthier aging at the cellular level

For anyone over 35, when NAD+ naturally declines, supporting your body with NAD+ supplementation or its precursors may be one of the most effective strategies to reclaim vitality.

Conclusion

This study reinforces that NAD+ is not a passing wellness trend but a science-backed pathway to healthier aging. By choosing supplements designed to restore NAD+, you can take an active role in supporting your energy, focus, and longevity.